Griseofulvin

• Griseofulvin is used to treat ringworm, athlete’s foot, jock itch, and fungal infections of the scalp, fingernails, or toenails.

Mechanism of action.

• It inhibits fungal mitosis by disrupting the mitotic spindle through interaction with polymerized microtubules.

Side effects.

• GI disturbance, dizziness, fatigue, and impaired judgment.
• Blood dyscrasia, hepatotoxicity, insomnia.
• Skin rashes, photosensitivity, oral thrush.

Contraindications.

• Avoid the drug during pregnancy or within one month of treatment.
• Men should not father children within six months of treatment.

· In case of liver failure.

· porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Drug interaction.

• Enhancement of alcoholic effects.
• Reduced response to barbiturate and anti-coagulants.

Dosage.

• 500mg- 1000mg daily.
• Tinea capitis: 4- 6 weeks
• Onychomycosis of fingernails: at least four months.
• Children 10mg/kg/day.